Formulation: A crystalline solid
Formal Name: 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride
Purity: ≥98%
Formula Markup: C27H30F2N2O3 • 2HCl
Formula Weight: 541,5
Shelf life (days): 1460
CAS Number: 101477-54-7
Notes: Lomerizine is a voltage-dependent calcium channel blocker that inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons with IC50 values of 1.9 and 4 μM, respectively.{53083,53084} It inhibits vasoconstriction induced by potassium chloride, serotonin (5-HT; Item No. 14332), or vasopressin in isolated rat basilar arteries when used at a concentration of 1 μM.{53083} Lomerizine (1 μM) reduces neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures.{53085} It reduces retinal damage in a rat model of retinal ischemia-reperfusion injury when administered at a dose of 1 mg/kg.
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