Formulation: A crystalline solid
Formal Name: N-[2-fluoro-5-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methyl-acetamide
Purity: ≥98%
Formula Markup: C20H15FN4O2S
Formula Weight: 394,4
Shelf life (days): 1460
CAS Number: 917393-39-6
Notes: Lorediplon is a ligand for α1 subunit-containing GABAA receptors.{40790} In vivo, lorediplon inhibits spontaneous motor activity and increases duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity.{40791} Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow wave sleep (SWS) and paradoxical sleep (PS) in mice.{40792} Formulations containing lorediplon have been used in the treatment of insomnia.
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