LSN2463359, CAS 1401031-52-4

Formulation: A crystalline solid

Formal Name: N-(1-methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C16H15N3O

Formula Weight: 265,3

Shelf life (days): 1460

CAS Number: 1401031-52-4

Notes: LSN2463359 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5; EC50 = 24 nM).{34519} It is without effect at other mGluRs. LSN2463359 is brain penetrant and reverses learning deficits in a rat model of schizophrenia.{34519,34521} Through its effects on mGluR5, LSN2463359 attenuates deficits in performance in operant behavior induced by SDZ-220581, an NMDA (Item No. 14581) receptor antagonist, in rats.{34520,34521} It also promotes wakefulness in animals.{34521}

• SKU: CAY22104-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22104-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK