Formulation: A crystalline solid
Formal Name: 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-ethanone
Purity: ≥98%
Formula Markup: C16H22N4O3
Formula Weight: 318,4
Shelf life (days): 1460
CAS Number: 88107-10-2
Notes: LY171883 is a selective, potent, orally active antagonist of the leukotriene D4 receptor.{1741} Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.{1741} LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 µM) and various guinea pig tissues (IC50s range from 6.9-209 µM).{1741} At a concentration of 50-100 µM, LY171883 binds to the PPARγ nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.{1618,1425}