LY272015, CAS 172895-15-7

Formulation: A solid

Formal Name: 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole, monohydrochloride

Purity: ≥98%

Formula Markup: C21H24N2O2 • HCl

Formula Weight: 372,9

Shelf life (days): 1460

CAS Number: 172895-15-7

Notes: LY272015 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B.{49231} It binds to 5-HT2B receptors in isolated rat fundus (Kb = 0.177 nM). LY272015 is selective for 5-HT2B receptors over 5-HT2A and 5-HT2C receptors (Kis = 3.54 and 2.1 nM, respectively), as well as α1-adrenergic receptors.{49231,52703} It reduces 5-HT-induced migration of isolated mouse aortic smooth muscle cells when used at a concentration of 100 nM.{52704} LY272015 (1 and 3 mg/kg) decreases mean arterial pressure in DOCA-salt hypertensive rats.{52705}

• SKU: CAY31471-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31471-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK