Formulation: A solid
Formal Name: glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-alaninamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C94H145N23O24 • XCF3COOH
Formula Weight: 1981,3
Shelf life (days): 1460
Notes: M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).{57419,67613} It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM).{57419} M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2 receptor (EC50 = 16.2 nM) and inhibits forskolin-induced cAMP accumulation in RIN-m5F pancreatic β-cells when used at concentrations of 10 or 100 nM.{57419,67613} In vivo, M40 (9.36 nmol/animal, i.c.v.) reverses galanin-induced inhibition of scopolamine-induced hippocampal acetylcholine (ACh) release in conscious rats.{67613} M40 reduces galanin-induced increases in food intake in rats. It improves cardiac function and decreases cardiac fibrosis in a rat model of heart failure induced by sustained coronary artery ligation when administered at a dose of 30 nmol/kg.{67614} M40 (20 µg/animal) increases the intromission frequency and ejaculation latency in sexually sluggish male mice.{67615}
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