Formulation: A crystalline solid
Formal Name: 5,6,6aS,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
Purity: ≥98%
Formula Markup: C20H24NO4
Formula Weight: 342,4
Shelf life (days): 1460
CAS Number: 2141-09-5
Notes: Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities.{48045,48046,48047,48048} It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 μM.{48045} Magnoflorine (10 μM) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABAA receptor antagonist bicuculline (Item No. 11727).{48046} It reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells.{48047} In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.{48048}
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