Formulation: A crystalline solid
Formal Name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
Purity: ≥98%
Formula Markup: C35H38N4O6
Formula Weight: 610,7
Shelf life (days): 1460
CAS Number: 89226-50-6
Notes: Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.
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