Formulation: A crystalline solid
Formal Name: 5-ethyl-2-[4-[4-[[4-(1H-tetrazol-1-yl)phenoxy]methyl]-2-thiazolyl]-1-piperidinyl]-pyrimidine
Purity: ≥98%
Formula Markup: C22H24N8OS
Formula Weight: 448,5
Shelf life (days): 1460
CAS Number: 1037792-44-1
Notes: MBX-2982 is an agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}
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