Formulation: A solid
Formal Name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C34H39N7O4 • XCF3COOH
Formula Weight: 609,7
Shelf life (days): 1460
Notes: MCL0020 is a melanocortin receptor 4 (MC4R) antagonist.{69903} It selectively inhibits [Nle4,D-Phe7]-α-MSH (Item No. 24475) binding to recombinant human MC4R over MC1R and MC3R (IC50s = 11.63, >10,000, and 1,115 nM, respectively). MCL0020 (0.1-100 µM) inhibits α-MSH-induced cAMP production in COS-1 cells expressing human MC4R. In vivo, MCL0020 (10 µg/animal; i.c.v.) reduces stress-induced decreases in the time spent in the light area of the light/dark exploration test, indicating anxiolytic-like activity, in mice. It also reverses restraint stress-induced decreases in food intake in rats.
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