McNA343, CAS 55-45-8

Formulation: A solid

Formal Name: 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride

Purity: ≥98%

Formula Markup: C14H18ClN2O2 • Cl

Formula Weight: 317,2

Shelf life (days): 1460

CAS Number: 55-45-8

Notes: McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays).{56099} It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective antagonists. McNA343 also inhibits forskolin-induced cAMP production in CHO cells expressing M1 or M4 receptors, as well as phosphatidylinositol hydrolysis in CHO-K1 cells expressing M3 receptors and CHO cells expressing M5 receptors. Intrathecal administration of McNA343 inhibits compulsive hindlimb neck-scratching behavior induced by 5’-guanidinonaltrindole (GNTI) in mice. It has nootropic activity, enhancing spontaneous working memory in the Y maze in wild-type mice, and it reverses learning and memory impairments induced by bulbectomy in mice in a passive avoidance test.

• SKU: CAY30961-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30961-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK