Formulation: A crystalline solid
Formal Name: α-phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Purity: ≥98%
Formula Markup: C20H25NO
Formula Weight: 295,4
Shelf life (days): 1460
CAS Number: 107703-78-6
Notes: MDL 11939 is a potent, orally bioavailable, and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 6.06 nM for the human receptor).{41330} It is selective for the human 5-HT2A receptor over human 5-HT2B and 5-HT2C and rat 5-HT2B receptors (Kis = 3,020, 1,020, and 4,700 nM, respectively), as well as 5-HT1, 5-HT1A, α1- and α2-adrenergic, dopamine D2, muscarinic acetylcholine, histamine, and opiate receptors.{41330,41333} MDL 11939 administered to rats prior to or following learned helplessness-induced stress prevents increases in acoustic startle response.{41331} MDL 11939 (10 mg/kg, i.v.) also has anti-arrhythmic activity in anesthetized dogs following myocardial infarction.{41332}
English
Deutsch
