MDV 3100, CAS 915087-33-1

Formulation: A crystalline solid

Formal Name: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-benzamide

Purity: ≥98%

Formula Markup: C21H16F4N4O2S

Formula Weight: 464,4

Shelf life (days): 1460

CAS Number: 915087-33-1

Notes: MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}

• SKU: CAY11596-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11596-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK