Formulation: A solid
Formal Name: rel-αS-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, monohydrochloride
Purity: ≥98%
Formula Markup: C17H16F6N2O • HCl
Formula Weight: 414,8
Shelf life (days): 1460
CAS Number: 51773-92-3
Notes: Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
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