Formulation: A crystalline solid
Formal Name: N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2→7)-lactam, acetate
Purity: ≥98%
Formula Markup: C50H69N15O9 • XC2H4O2
Formula Weight: 1024,2
Shelf life (days): 1460
Notes: Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors).{52012} It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory nerve conduction velocity when administered at a dose of 20, but not 2 or 50, µg/kg.{52013} Melanotan II (1 nmol, i.c.v.) increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol (Item No. 9003100) in chow-fed and diet-induced obese rats.{52014}
English
Deutsch
