Formulation: A solid
Formal Name: 3,5-di(methyl-d3)-tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C12H15D6N • HCl
Formula Weight: 221,8
Shelf life (days): 1460
CAS Number: 1189713-18-5
Notes: Memantine-d6 is intended for use as an internal standard for the quantification of memantine (Item No. 14184) by GC- or LC-MS. Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory deficits in the AAV1-I1PP2A rat model of Alzheimer's disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}
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