Formulation: A lyophilized powder
Formal Name: L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C27H35N5O7S • XCF3COOH
Formula Weight: 573,7
Shelf life (days): 1460
Notes: Met-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ- and µ-opioid receptors (Kis = 0.65 and 1.7 nM, respectively).{42332,25533} It is selective for δ- and µ- over κ-opioid receptors (Ki = >1,000 nM).{25533} Met-Enkephalin is a cleavage product of proenkephalin, which is found primarily in the adrenal medulla and the CNS.{42333} Met-Enkephalin is found in the brain, primarily in the globus pallidus, nucleus accumbens, and substantia nigra, the brainstem, and the spinal cord as well as in the peripheral nervous system.{42333,42334} Met-Enkephalin has antinociceptive effects in mouse models of acute pain, including tail pressure, hot plate tail-flick, and acetic acid-induced writhing tests (ED50s = 170, 140, and 88 nmol/animal, respectively).{42335} Levels of Met-enkephalin are increased at the site of inflammation in a complete Freund’s adjuvant mouse model of chronic inflammatory pain.{42336}
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