Formulation: A crystalline solid
Formal Name: 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol, hemisulfate
Purity: ≥98%
Formula Markup: C11H17NO3 • 1/2H2SO4
Formula Weight: 260,3
Shelf life (days): 1460
CAS Number: 5874-97-5
Notes: Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions.{40372} It inhibits TGF-α-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the β2-AR antagonist butoxamine but not the β1-AR antagonist metoprolol (Item No. 15429).{40371} Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively).{40373} Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma.