Formulation: A crystalline solid
Formal Name: N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-1,2-ethanediamine, monohydrochloride
Purity: ≥98%
Formula Markup: C14H19N3S • HCl
Formula Weight: 297,8
Shelf life (days): 1460
CAS Number: 135-23-9
Notes: Methapyrilene is a histamine H1 receptor antagonist (Ki = 4.5 nM) and non-genotoxic carcinogen.{23220,61262} Dietary administration of methapyrilene (0.1%) induces liver tumors in rats, with greater than 50% of rats incurring distant metastases.{61263} It decreases the acetylation of histone 3 lysine 9 (H3K9) and H3K56, as well as the di- and trimethylation of H3K4 and H4K20, respectively, in rat liver when administered at 40 mg/kg per day for six weeks.{61262} Methapyrilene also increases 4-hydroxy nonenal (4-NHE) protein adducts in rat liver. Formulations containing methapyrilene were previously used as sleep aids.
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