Formulation: A crystalline solid
Formal Name: N1,N8-bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine, tetrahydrochloride, hydrate
Purity: ≥95%
Formula Markup: C36H62N4O2 • 4HCl [XH2O]
Formula Weight: 728,8
Shelf life (days): 1460
Notes: Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).{41412} It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 µM.{36588} In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholine (Item No. 23829) in guinea pigs with ED50 values of 38 and 81 nmol/kg, respectively. In a rat model of spinal cord injury, methoctramine suppresses bladder overactivity induced by the non-selective muscarinic acetylcholine receptor agonist oxotremorine M (Item No. 20847).{36589}
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