Formulation: A crystalline solid
Formal Name: 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-phenol, 1-acetate, monohydrochloride
Purity: ≥98%
Formula Markup: C17H27NO4 • HCl
Formula Weight: 345,9
Shelf life (days): 730
CAS Number: 36592-77-5
Notes: Metipranolol is a β-adrenergic receptor (β-AR) antagonist.{43071} It binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM) and inhibits relaxation induced by isoproterenol (Item No. 15592) in guinea pig atrium and by fenoterol (Item No. 21293) in rat uterus (pA2s = 8.3 and 8.4, respectively). In vitro, metipranolol (100 μM) inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates.{43072,43073} In vivo, topical ocular application of metipranolol (0.3%) decreases α-chymotrypsin-induced increases in intraocular pressure (IOP) in rabbits.{43071} It also inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
English
Deutsch
