Formulation: A solid
Formal Name: 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate
Purity: ≥95%
Formula Markup: C20H23NS • HCl [H2O]
Formula Weight: 363,9
Shelf life (days): 1460
CAS Number: 7081-40-5
Notes: Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs; Ki = 15 nM for the rat receptor).{69560} It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE; IC50 = 1.6 µM for the horse enzyme) in cell-free assays.{69561} Metixene reduces the proliferation of P388 leukemia and doxorubicin-resistant P388 (P388/ADR) cells (EC50s = 10 and 12 µM, respectively).{69562} It induces apoptosis in BT474 and MDA-MB-231 breast cancer cells when used at a concentration of 15 µM and induces autophagy in the same cells at 10 µM.{69563} In vivo, metixene (1 mg/kg three times per week) decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model.
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