Formulation: A solid
Formal Name: 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(methoxy-d3)benzamide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C14H19ClD3N3O2
Formula Weight: 302,8
Shelf life (days): 1460
CAS Number: 1216522-89-2
Notes: Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide (Item No. 23360) by GC- or LC-MS. Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.{36215,36216} It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes).{36216} Oral administration of metoclopramide inhibits emesis induced by cisplatin (Item No. 13119) and apomorphine (Item No. 16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively.{36215,36216} Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).{36217} Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.{36218,36219}
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