Formulation: A solid
Formal Name: 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]-benzoic acid
Purity: ≥95%
Formula Markup: C27H21F3N2O3
Formula Weight: 478,5
Shelf life (days): 1460
CAS Number: 1050656-06-8
Notes: MF766 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (Ki = 0.23 nM).{62588} It is selective for EP4 over the PGD2 receptor subtype DP1 (Ki = 1,648 nM) as well as the EP1, EP2, EP3, and CRTH2/DP2 receptors, the PGI2 receptor (IP), thromboxane receptor (TP), and PGF receptor (FP; Kis = >6,000 nM for all). It inhibits cAMP accumulation induced by PGE2 (Item No. 14010) in HEK293 cells (IC50 = 1.3 nM). MF766 (312.5 and 1,250 nM) reverses PGE2-induced decreases in IFN-γ production in IL-2-stimulated primary human natural killer cells.{62589} It reduces paw edema in a rat model of adjuvant-induced arthritis in a dose-dependent manner.{62588} MF766 (30 mg/kg) inhibits tumor growth in a CT26 murine colon cancer model.{62589}
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