Formulation: A solid
Formal Name: 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-3,4-phenanthrenedione
Purity: ≥95%
Formula Markup: C19H22O2
Formula Weight: 282,4
Shelf life (days): 1460
CAS Number: 27210-57-7
Notes: Miltirone is a tanshinone that has been found in S. miltiorrhiza and has diverse biological activities.{62725,62726,62727,62728,62729} It protects lard from thermal oxidation when used at a concentration of 0.02%.{62725} Miltirone is a partial agonist of the benzodiazepine receptor (IC50 = 0.3 µM).{62726} It inhibits carboxylesterase 2 (CES2; Ki = 0.04 µM) as well as severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), also known as 3C-like protease (3CLpro), and papain-like protease (PLpro; IC50s = 21.1 and 30 µM, respectively).{62727,62728} Miltirone is cytotoxic to HCT116 colon cancer cells (IC50 = 4.27 µM) and induces mitochondrial dysfunction and the production of reactive oxygen species (ROS) in the same cells.{62729} In vivo, miltirone (10-60 mg/kg) increases the number of punished crossings in the four-plate test, indicating tranquilizing activity, in mice.{62726}
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