Formulation: A solid
Formal Name: (αE,2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
Purity: ≥98%
Formula Markup: C23H30N2O4
Formula Weight: 398,5
Shelf life (days): 730
CAS Number: 14509-92-3
Notes: Mitraciliatine is an alkaloid that has been found in M. speciosa (Kratom in Thai) and is a μ-opioid receptor (MOR) partial agonist and κ-opioid receptor (KOR) agonist.{20201,67185} It is selective for MOR and KOR over the δ-opioid receptor (DOR; EC50s = 228, 218, and >1,000 nM, respectively, for the mouse receptors in a GTPγS binding assay).{67185} Mitraciliatine (100 nmol/animal, i.c.v.) increases the latency to withdrawal in the warm water tail withdrawal assay in mice, an effect that can be reversed by knockout of MOR but not KOR. Unlike morphine, mitraciliatine does not induce hyperlocomotion or respiratory depression.
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