MK-0812, CAS 624733-88-6

Formulation: A crystalline solid

Formal Name: 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)- 3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol

Purity: ≥98%

Formula Markup: C24H34F3N3O3

Formula Weight: 469,5

Shelf life (days): 1460

CAS Number: 624733-88-6

Notes: MK-0812 is an antagonist of chemokine (C-C) motif receptor 2 (CCR2; IC50 = 5 nM for the human receptor).{34341} It inhibits mammosphere formation of BT-549 breast cancer cells, an effect that is enhanced by the β-catenin inhibitor PNU 74654 (Item No. 16349).{64324} MK-0812 (0.03, 0.1, and 0.3 mg/kg) increases chemokine (C-C) motif ligand 2 (CCL2) levels and decreases CD11b+ monocytes in mouse blood.{34340}

• SKU: CAY21803-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21803-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK