Notes: MK-7622 is a positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs).{61527} It increases ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM). MK-7622 (0.3 and 1 mg/kg) reverses scopolamine-induced cognitive deficits in an object retrieval detour task in rhesus macaques.