Formulation: A crystalline solid
Formal Name: (5R,10S)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate
Purity: ≥95%
Formula Markup: C16H15N • C4H4O4
Formula Weight: 337,4
Shelf life (days): 1460
CAS Number: 121917-57-5
Notes: (–)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019).{26258} In vivo, (–)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg).{45209} (–)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity.{45210} (–)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 μM for electric eel and rat brain AChE, respectively.{45211}
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