Formulation: A crystalline solid
Formal Name: 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole, monohydrochloride
Purity: ≥98%
Formula Markup: C18H18BrFN2O • HCl
Formula Weight: 413,7
Shelf life (days): 1460
CAS Number: 1706524-94-8
Notes: ML-00253764 is a melanocortin receptor 4 (MC4R) antagonist (Ki = 0.16 µM).{51180} It is selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively).{51181} ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH; Item No. 24475) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes. It prevents the loss of lean body mass and enhances light-phase food consumption in a Lewis lung carcinoma (LLC) mouse model but does not reduce tumor size when administered at a dose of 15 mg/kg.
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