Notes: ML-365 is a bis-amide TASK-1 potassium channel blocker (IC50 = 16 nM).{42066} It is selective for TASK-1 over TASK-3 channels in a QPatch assay (IC50 = 990 nM). It also acts as an antagonist of the metabotropic glutamate receptor mGluR5 (IC50 = 1.35 μM).{42067}