ML-396, CAS 1630936-95-6

Formulation: A solid

Formal Name: N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C17H11Cl2N3O2

Formula Weight: 360,2

Shelf life (days): 1460

CAS Number: 1630936-95-6

Notes: ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.{46721} ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.{46722}

• SKU: CAY29167-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29167-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK