Formulation: A solid
Formal Name: 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-methanone
Purity: ≥98%
Formula Markup: C22H25N3O3
Formula Weight: 379,5
Shelf life (days): 1460
CAS Number: 1386162-69-1
Notes: ML-417 is a dopamine D3 receptor agonist.{67369} It is selective for the dopamine D3 receptor over the dopamine D2 receptor (EC50s = 38 and >10,000 nM, respectively, in β-arrestin recruitment assays using CHO-K1 cells expressing the human receptors) and dopamine D1, D4, and D5 receptors, as well as a panel of 45 G protein-coupled receptors (GPCRs), transporters, and ion channels at 10 µM. ML-417 inhibits forskolin-induced cAMP accumulation in HEK293 cells expressing the human dopamine D3 receptor (IC50 = 86 nM) and induces phosphorylation of ERK in CHO-K1 cells expressing the human dopamine D3 receptor (EC50 = 21 nM). It protects against cell death induced by the catecholaminergic neurotoxin 6-OHDA (Item No. 25330) in human induced pluripotent stem cell-derived (iPSC-derived) cells differentiated into dopaminergic neurons when used at a concentration of 50 nM.
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