Formulation: A crystalline solid
Formal Name: 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥98%
Formula Markup: C22H22N2O3
Formula Weight: 362,4
Shelf life (days): 1460
CAS Number: 332382-54-4
Notes: ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1).{46901} It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Item No. 20425) prior to isolation from HEK293 cells expressing TRPML1. It also activates whole-endolysosome IML1 in primary murine macrophages.