Formulation: A solid
Formal Name: 3-(diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]-imidazo[1,2-a]pyridinium, monobromide
Purity: ≥98%
Formula Markup: C29H26N2PS • Br
Formula Weight: 545,5
Shelf life (days): 1460
CAS Number: 1345964-89-7
Notes: ML-154 is an antagonist of the neuropeptide S receptor (NPSR; IC50 = 3.5 nM).{46808} It is selective for NPSR over arginine vasopressin (AVP) receptor V1B, as well as a panel of 55 receptors, channels, and transporters at 10 µM.{46809,46808} ML-154 reduces NPS-induced calcium mobilization, cAMP formation, and ERK activation with IC50 values of 0.96, 45, and 1.3 nM, respectively, in CHO cells expressing NPSR.{46808} It reduces alcohol self-administration and the progressive ratio breakpoint, but not cue- or stress-induced reinstatement of alcohol-seeking behavior, in rats when administered intraperitoneally at a dose of 1 mg/kg.{46809} ML-154 (10 µg, i.c.v.) inhibits decreases in food intake induced by intracerebroventricular administration of NPS in rats.{46808}
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