Formulation: A solid
Formal Name: N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-benzamide
Purity: ≥98%
Formula Markup: C15H14Cl2N2O3S
Formula Weight: 373,3
Shelf life (days): 1460
CAS Number: 825658-06-8
Notes: ML-335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 µM, respectively, in Xenopus oocytes).{47628} It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML-335 activates K2P2.1/TREK1 by binding to the C-type gate, which is the active site of TREK channels.