Formulation: A solid
Formal Name: 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-2-furancarboxylic acid
Purity: ≥95%
Formula Markup: C15H14O7
Formula Weight: 306,3
Shelf life (days): 1460
CAS Number: 313254-94-3
Notes: MMG-11 is an antagonist of the toll-like receptor 1/2 (TLR1/2) heterodimer (IC50 = 0.9 µM in HEK-Blue cells expressing the human receptors).{66437} It is selective for TLR1/2 over the TLR2/6 heterodimer (IC50 = 7.4 µM in HEK-Blue cells expressing the human receptors). MMG-11 inhibits TNF-α and IL-6 cytokine secretion induced by the bacterial lipopeptide agonist of TLR2, Pam3CKS4 (Item No. 24126), in RAW 264.7 macrophages (IC50s = 3.3 and 0.2 µM, respectively). It increases serotonin transporter (SERT) and glutathione (GSH) activity, as well as decreases lactate dehydrogenase (LDH) activity and malondialdehyde (MDA) levels, in M. avium-infected Caco-2 cells when used at a concentration of 5 ng/ml.{66438}
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