Formulation: A crystalline solid
Formal Name: L-leucyl-L-α-glutamyl-L-seryl-L-isoleucyl-L-phenylalanyl-L-arginyl-L-seryl-L-leucyl-L-leucyl-L-phenylalanyl-L-arginyl-L-valyl-L-methionine, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C75H123N19O18S • XCF3COOH
Formula Weight: 1611
Shelf life (days): 1460
Notes: MMK1 is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1).{54482} MMK1 induces calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = α16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner.{54483} MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes. Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.{54484}
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