Formulation: A solid
Formal Name: (2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-dihydroxy-4-((methoxy-d3)imino)-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C37H50D3NO8
Formula Weight: 642,8
Shelf life (days): 1460
Notes: Moxidectin-d3 is intended for use as an internal standard for the quantification of moxidectin (Item No. 17165) by GC- or LC-MS. Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin.{28538,45405} It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.{45405} Moxidectin (0.2 and 0.3 mg/kg) reduces worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.{45406} Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.
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