Formulation: A crystalline solid
Formal Name: 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine
Purity: ≥95%
Formula Markup: C9H12ClN5O
Formula Weight: 241,7
Shelf life (days): 1460
CAS Number: 75438-57-2
Notes: Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}
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