MRS1754, CAS 264622-58-4

Formulation: A crystalline solid

Formal Name: N-(4-cyanophenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide

Purity: ≥95%

Formula Markup: C26H26N6O4

Formula Weight: 486,5

Shelf life (days): 1460

CAS Number: 264622-58-4

Notes: MRS1754 is an adenosine A2B receptor antagonist (Ki = 1.97 nM).{32640} It is selective for adenosine A2B receptors over adenosine A1, A2A, and A3 receptors (Kis = 403, 503, and 570 nM, respectively). In vivo, MRS1754 (0.5-10 mg/kg) increases 28-day survival, as well as decreases peritoneal bacterial growth and plasma levels of IL-6, TNF-α, and MIP-2, in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{59911} MRS1754 (1 mg/kg) reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).{59912}

• SKU: CAY33501-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33501-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK