Formulation: A solid
Formal Name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propyn-1-yl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester
Purity: ≥95%
Formula Markup: C21H22N2O6
Formula Weight: 398,4
Shelf life (days): 1460
CAS Number: 544478-19-5
Notes: MRS1845 is an inhibitor of store-operated calcium (SOC) channels (IC50 = 1.7 µM in HL-60 leukemia cells) and the L-type voltage-gated calcium channel Cav1 (IC50 = 2.1 µM in GH4C1 rat pituitary cells).{67159} It reduces calcium entry induced by the sarcoplasmic/endoplasmic Ca2+-ATPase (SERCA) inhibitor thapsigargin (Item No. 10522) in isolated rat polymorphonuclear leukocytes (PMNs) after administration of a 1.2 mg/kg dose.{67160} MRS1845 (1.2 mg/kg) decreases shock-induced increases in ITGAM/CD11b levels in PMNs isolated from rats in a model of traumatic hemorrhagic shock.
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