Formulation: A crystalline solid
Formal Name: 8-chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥98%
Formula Markup: C17H17ClN4
Formula Weight: 312,8
Shelf life (days): 1460
CAS Number: 6104-71-8
Notes: N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 / 25779).{25512} It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.{47099,47100} N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.{47100,25512,47101} N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice.{47102}
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