Formulation: A solid
Formal Name: (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-4,8-methano-8aH-bisbenzofuro[3,2-e:2′,3′-g]isoquinoline-1,8a-diol, methanesulfonate
Purity: ≥98%
Formula Markup: C26H25NO4 • CH3SO3H
Formula Weight: 511,6
Shelf life (days): 1460
CAS Number: 122517-78-6
Notes: Naltriben is an inverse agonist of δ2-opioid receptors (Ki = 0.013 nM in CHO-DG44 cells expressing the mouse receptor).{25533,65800} It is selective for δ2-opioid receptors over κ- and μ-opioid receptors (Kis = 13 and 12 nM in PC12 and COS-7 cells expressing the mouse and rat receptors, respectively). Naltriben (1 and 10 µM) induces axonal retraction in primary mouse hippocampal neurons under both normoxic and hypoxic conditions.{65798} It is also an activator of transient receptor potential melastatin 7 (TRPM7) and induces calcium influx in HEK293 cells expressing mouse TRPM7 (EC50 = 20.7 µM).{65799} It reduces self-administration of alcohol or alcohol mixed with saccharin or quinine in alcohol-preferring rats when administered at a dose of 6 mg/kg.{65800}
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