NAN-190, CAS 115338-32-4

Formulation: A crystalline solid

Formal Name: 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-1H-isoindole-1,3(2H)-dione, monohydrobromide

Purity: ≥95%

Formula Markup: C23H27N3O3 • HBr

Formula Weight: 474,4

Shelf life (days): 1460

CAS Number: 115338-32-4

Notes: NAN-190 is a mixed antagonist and partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{45661} It inhibits radioligand binding to 5-HT1A sites in rat hippocampal membranes (Ki = 2 nM). NAN-190 decreases 5-carboxamidotryptamine-mediated inhibition of forskolin-induced adenylyl cyclase activity in guinea pig hippocampal membranes in a concentration-dependent manner, indicating partial agonist activity. NAN-190 also antagonizes α1-adrenergic receptors (α1-ARs; pA2s = 9.47, 9.02, and 9.99 in isolated rat tail artery, rabbit aorta, and rat aorta, respectively).{45662} In vivo, NAN-190 (1-300 μg/kg) decreases blood pressure, without modifying heart rate, in anesthetized rats. It inhibits phenylephrine-induced pressor responses in pithed rats. NAN-190 (5 mg/kg, i.p.) potentiates the circadian response to light in dark-adapted and entrained hamsters.{45663}

• SKU: CAY29314-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29314-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK