Formulation: A solid
Formal Name: (3R,4aR,10aS)-3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione
Purity: ≥70%
Formula Markup: C25H30Cl2O5
Formula Weight: 481,4
Shelf life (days): 1460
CAS Number: 103106-24-7
Notes: Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities.{53567,53568} It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 µg/ml).{53567} Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 µM in rat uterine homogenates).{53568} It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively).{53569}