Nav1.7 Blocker 52, CAS 1211866-85-1

Formulation: A solid

Formal Name: N-[2-methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]-acetamide

Purity: ≥98%

Formula Markup: C25H27F3N6O3

Formula Weight: 516,5

Shelf life (days): 1460

CAS Number: 1211866-85-1

Notes: Nav1.7 blocker 52 is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7; IC50 = 0.17 µM).{63077} It is selective for Nav1.7 over human-ether-a-go-go (hERG), also known as Kv11.1, Nav1.5, and Nav1.8 (IC50s = >10, 1.1, and 2.2 µM, respectively) but does inhibit Nav1.3 and Nav1.4 (IC50s = 0.3 and 0.4 µM, respectively). Nav1.7 blocker 52 (20 and 30 mg/kg) inhibits formalin-induced flinching in a rat model of persistent pain. It also increases the latency to paw withdrawal in a hot plate test in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA).{63078}

• SKU: CAY34477-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34477-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK