Formulation: A lyophilized powder
Formal Name: L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-serylglycyl-L-valyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-arginyl-L-arginyl-L-alanyl-L-lysyl-L-glutamine
Purity: ≥95%
Formula Markup: C95H160N34O27
Formula Weight: 2210,5
Shelf life (days): 1460
CAS Number: 412938-75-1
Notes: Neuropeptide S is a neuropeptide that is an agonist of the neuropeptide S receptor (NPSR) with an EC50 value of 3.2 nM for the rat peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor.{14301} In rats, it increases the duration of wakefulness and decreases slow wave sleep stage 1 (SWS1), SWS2, and rapid eye movement (REM). Neuropeptide S dose-dependently (0.5-4 nmol per animal, i.c.v.) decreases fecal pellet excretion induced by restraint stress or corticotropin releasing factor (CRF) but does not influence basal gastric emptying, gastrointestinal transit, or distal colon propulsion.{40683} It also inhibits audible and ultrasonic vocalizations and increases the percentage of time spent in the open arm of the elevated plus maze test in a mouse model of arthritis.{40684}
English
Deutsch
