Formulation: A solid
Formal Name: L-tyrosyl-L-prolyl-L-seryl-L-lysyl-L-prolyl-L-α-aspartyl-L-asparaginyl-L-prolylglycyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-prolyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-leucyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl- L-tyrosinamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C190H287N55O57 • XCF3COOH
Formula Weight: 4253,7
Shelf life (days): 1460
Notes: Neuropeptide Y (NPY) is a neuropeptide involved in appetite, vasoconstriction, cardiac contractility, and intestinal secretion and an agonist of the NPY receptors Y1, Y2, and Y5.{5565,41608} It is expressed throughout the body.{5565} NPY selectively inhibits forskolin-induced cAMP accumulation in L-M(TK-) cells expressing rat Y1 or Y2 and HEK293 cells expressing rat Y5 over L-M(TK-) cells expressing rat Y4 receptors (EC50s = 0.15, 2.7, 0.66, and >1,000 nM, respectively).{41608} It increases perfusion pressure in isolated guinea pig heart (EC30 = 1.3 nM).{51408} Intracerebroventricular administration of NPY (300 pmol/animal) increases food intake in rats.{41608}
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