Formulation: A solid
Formal Name: 3-piperidinecarboxylic acid
Purity: ≥95%
Formula Markup: C6H11NO2
Formula Weight: 129,2
Shelf life (days): 1460
CAS Number: 498-95-3
Notes: Nipecotic acid is an inhibitor of GABA transporters (GAT; IC50s = 2.6, 310, 29, and 16 µM for mouse GAT-1, GAT-2, GAT-3, and GAT-4, respectively).{45691} It does not bind GABAA or GABAB receptors (IC50s = >100 µM for both) but does bind the adenosine A3 receptor (IC50 = 0.01 µM).{53818,57961} Nipecotic acid inhibits GABA uptake in isolated rabbit choroid plexus (IC50 = 244 µM).{45693} It inhibits lactate dehydrogenase (LDH) release (EC50 = ~5 µM) and aggregation of a mutant form of huntingtin, htt-N63-148Q, in PC12 cells.{42775} Intraventricular administration of nipecotic acid (300 µg/animal) decreases tail flick reaction time in a rat model of morphine-induced analgesia.{36160}
English
Deutsch
